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The Pantanal, Brazil’s vast tropical wetland, is a bucket-list destination for nature lovers and wildlife enthusiasts. This biodiversity hotspot promises an unforgettable adventure, but best prepare against possible illness with vaccinations and health information before setting off.
Why Travel Health Matters in the Pantanal
The Pantanal’s remote, humid environment brings unique health risks including mosquito-borne diseases like yellow fever and malaria. As a travel clinic with locations in Massachusetts, we’ve helped many travelers prepare for a visit to this region. Whether you’re spotting wildlife along the Transpantaneira or boating through flooded plains, our same-day yellow fever vaccine appointments and tailored guidance keep you covered.
Yellow Fever Vaccine: A Must for Pantanal, Brazil
The yellow fever virus, spread by mosquitoes, is a serious risk in the Pantanal. The CDC recommends vaccination for all travelers aged 9 months and older heading to Mato Grosso and Mato Grosso do Sul, exactly where the Pantanal lies. As a CDC-certified Yellow Fever vaccination site, Destination Health Clinic provides the yellow fever vaccine and the official “yellow card” you may need for border checks (if crossing into Bolivia or Paraguay on your Pantanal adventure) or future travel.
- Why It’s Essential: Yellow fever can be severe, and vaccination is your best defense. While Brazil doesn’t require it for entry direct from the United States, it’s still critical for your safety in this risk area.
- Timing: It’s best to be vaccinated at least 10 days before departure for full protection, and one dose typically lasts a lifetime.
Malaria Prevention: Stay Bite-Free
Malaria risk can vary across the Pantanal, with the CDC noting risk primarily in Mato Grosso but not in Cuiabá or Mato Grosso do Sul. While there’s no vaccine, we’ve got you covered with antimalarial medication (if needed) and practical tips.
- Medication Options: Several options are available and we’ll recommend the best one for you depending on your plans and health history.
- Mosquito Protection: Pack DEET repellent (20% to 50%) and pre-treat clothing with permethrin.
If you spike a fever during or after your trip (up to a year later), seek medical advice and mention your Pantanal visit to your clinician.
Other mosquito illnesses are known to occur in the Pantanal, Brazil include dengue fever and chikungunya. We’ll provide additional advice about these diseases too.

Other Vaccines to Consider for Pantanal, Brazil
Beyond yellow fever, traveling to Brazil’s Pantanal calls for additional precautions:
- Typhoid Fever: Recommended for all Pantanal travelers. Food and water can carry this bacterial illness in rural Brazil.
- Hepatitis A: Another food and water risk illness, this vaccine is a smart choice for the Pantanal’s remote dining options.
- Routine Boosters: Ensure you’re up-to-date on measles-mumps-rubella (MMR), tetanus-diphtheria-pertussis (Tdap), and other routine immunizations. We’ll give you a full list of suggestions during an appointment.
Why Choose Destination Health Clinic for the Pantanal?
Massachusetts travelers love the Pantanal’s wild beauty, and we’ll help you prepare for adventure . Our locations offer:
- Specialty Vaccines: Yellow fever, typhoid, and more, all in stock.
- Expert Advice: We’ve prepped Pantanal-bound clients before and our staff is specially trained in travel health topics
- Competitive Prices: We keep costs down so you pay less for travel vaccines
Book online or call the office nearest you today!
