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Cape Town and Table Mountain: Malaria, Yellow Fever, and Vaccines
Planning a trip to Cape Town and Table Mountain in South Africa? This vibrant destination offers stunning landscapes, rich culture, and iconic attractions like Table Mountain. To ensure a safe and healthy adventure, understanding the health requirements—such as malaria medication, yellow fever vaccination, and other travel vaccines—is essential. At Destination Health Travel Clinic, we’re here to guide you through the key health considerations for your journey, tailored to Cape Town’s unique environment. This guide is designed to help you prepare, whether you’re exploring Table Mountain and surrounding natural areas or sticking to the sites within the city.
Is Malaria Medication Needed for Cape Town and Table Mountain?
Malaria is a mosquito-borne disease that poses a risk in certain parts of South Africa, but the good news for travelers to Cape Town and Table Mountain South Africa is that these areas are malaria-free. According to the Centers for Disease Control and Prevention (CDC), Cape Town, including the Western Cape region where Table Mountain is located, has no known malaria transmission. This means that malaria medication is not necessary for visitors staying in and around Cape Town.
However, if your itinerary extends beyond Cape Town to malaria-risk areas of South Africa, such as Kruger National Park or parts of Limpopo, Mpumalanga, or KwaZulu-Natal Provinces, you may need to take anti-malaria tablets. Risk for malaria in these regions is typically higher in the months of September to May.
And remember, always use mosquito bite prevention measures, such as DEET-based repellents, long-sleeved clothing, and mosquito nets.

Is Yellow Fever Vaccination Necessary for Cape Town?
Yellow fever is not present in South Africa, including Cape Town and Table Mountain, so there is no risk of contracting yellow fever disease in these areas. However, South Africa has specific entry requirements regarding yellow fever vaccination to prevent its importation from other countries.
You must present a valid yellow fever vaccination certificate (International Certificate of Vaccination or Prophylaxis, or ICVP) IF you:
Arrive from a country with a risk of yellow fever (e.g., parts of Africa or South America, such as Kenya, Uganda, or Brazil).
- Transiting for more than 12 hours through an airport in a yellow fever risk country.
In these cases, the yellow fever vaccination is required and travelers must be immunized at least 10 days before arrival to South Africa.
However, if you’re traveling directly from the United States or Europe without stopping in a yellow fever country, you do not need the yellow fever vaccine and the entry requirement does not apply.

Recommended Travel Vaccines for Cape Town
While malaria and yellow fever may not be concerns in Cape Town, other travel vaccines and health precautions are recommended to protect against common diseases. The CDC and World Health Organization (WHO) suggest the following for most travelers to Cape Town, South Africa:
Hepatitis A: Transmitted through contaminated food or water, this vaccine is highly recommended, especially if you plan to eat at local markets or street food stalls in Cape Town.
Typhoid Fever: Another food and waterborne illness, typhoid vaccination is advised for adventurous eaters or those venturing to less developed areas outside of Cape Town.
Hepatitis B: Recommended for travelers who may need medical treatment, engage in sexual activity, or staying more than a few weeks in South Africa.
Rabies: Consider vaccination if you plan to spend time in rural areas or interact with animals, and be especially careful around stray dogs and Cape fur seals at beaches to avoid bites or scratches.
- Routine Vaccinations: Ensure you’re also up-to-date on these vaccines before a trip to Cape Town, South Africa:
- MMR (measles, mumps, rubella): Protect with two doses of MMR before international travel as measles spreads easily between people when tiny droplets circulate in the air after coughing and sneezing
- Tdap (tetanus, diphtheria, pertussis): this 3-in-1 vaccine protects against bacteria infection from cuts and scratches but also whooping cough (pertussis) which transmits easily in crowded spaces like airports and markets.
- Influenza, and COVID-19 are also important especially if visiting South Africa in winter months.

Additional Health Considerations for Cape Town
Beyond vaccinations, here are other health tips to ensure a safe trip:
Food and Water Safety: Stick to bottled or purified water and avoid raw or undercooked foods to prevent travelers’ diarrhea. Use hand sanitizer and wash hands frequently.
Sun Protection: Cape Town’s sunny climate calls for sunscreen, hats, and light, long-sleeved clothing to protect against UV exposure, especially during summer (December–February).
Travel Health Insurance: Secure comprehensive travel health insurance that covers all medical care and evacuation.
- Crime and Personal Safety: non-violent and violent crime can be common in areas of Cape Town and South Africa. Guard valuables in crowds, avoid wearing jewelry and watches, and best not to stay out on streets late at night.
Why Choose Destination Health Travel Clinic?
At Destination Health Travel Clinic, we specialize in preparing travelers for safe adventures to destinations like Cape Town and Table Mountain, South Africa. Our team stays updated on the latest CDC and WHO guidelines to provide accurate advice with lower travel vaccine prices than national chain travel clinics.
Book your appointment at any of our convenient Massachusetts locations today, and experience the difference of a locally owned travel clinic.
